GLP-1 weight management
Once-weekly medications that reduce appetite and cravings. Learn how they work, how doses step up, and what the trials found.
- Semaglutide
- Tirzepatide
- Retatrutide (investigational)
New GLP-1 guides and dose calculator
Guiding you with science. Supporting you with care.
Clear, evidence-based information about GLP-1 medications and peptides: how they work, what the research shows, and how dosing works, so you can have better conversations with your own provider.
- Plain-language guides
- Research-backed
- Free dose tools
- Evidence firstInformation drawn from published clinical research.
- Practical toolsDose calculator, injection guide, and side-effect guide.
- Questions welcomeEmail us anytime for a plain-language answer.
- Based in North Texas4394 Sunbelt Drive, Addison, TX 75001.
Topics
Two areas, explained clearly
Whether you're curious about weight management, recovery, or healthy aging, these guides help you understand the options before you talk with your provider.
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GLP-1 medications
Find the medication that fits your journey
The world of GLP-1 medications can feel overwhelming. Here's a plain-language look at each option.
GLP-1 receptor agonist
Semaglutide
The most widely studied GLP-1 medication. It reduces appetite and cravings with a single injection each week.
Read more
GIP + GLP-1 dual agonist
Tirzepatide
Acts on two hormone pathways instead of one. In trials it produced greater average weight loss than GLP-1 alone.
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GIP + GLP-1 + glucagon
Retatrutide
A next-generation triple-hormone medication. Investigational and not FDA approved, prescribed only under licensed supervision.
Read more
The research
What the clinical trials found
Average results from the largest clinical trials of each medication, measured over a year or more of treatment.
14.9%
Average weight loss with semaglutide
Adults taking semaglutide 2.4 mg weekly for 68 weeks, compared with 2.4% on placebo.
STEP 1 trial, New England Journal of Medicine, 202120.9%
Average weight loss with tirzepatide
Adults taking tirzepatide 15 mg weekly for 72 weeks, compared with 3.1% on placebo.
SURMOUNT-1 trial, New England Journal of Medicine, 202228.3%
Average weight loss with retatrutide
Adults taking retatrutide 12 mg weekly for 80 weeks, compared with 2.2% on placebo. Still investigational.
TRIUMPH-1 phase 3 trial, Eli Lilly topline results, 2026Trial participants also received lifestyle counseling. Results in everyday practice are often lower than in tightly controlled trials, and individual results vary.
Results
What progress typically looks like
Results vary from person to person. These are ranges commonly reported with consistent use.
Semaglutide
- Weeks 4–84–15 lbs
Early loss is driven mostly by lower appetite, smaller portions, and fewer cravings.
- Weeks 12–1515–26 lbs
As your dose increases, appetite control and healthier eating habits become more consistent.
Tirzepatide
- Weeks 4–86–18 lbs
Reduced appetite and cravings lead to early, noticeable changes.
- Weeks 12–1518–30 lbs
Continued appetite regulation and steady habits support more significant progress.
How to use this site
From first question to a better conversation
Explore your options
Read plain-language guides to GLP-1 medications and peptides, with the research behind them.
Reach out with questions
Email us or send a message. We'll answer in plain language, with no pressure.
Talk with your provider
Bring what you've learned to your own licensed provider, who decides what's right for you.
Peptides
Ten peptides, explained
From recovery to energy to healthy aging, learn what each peptide is, what the research shows, and how it's typically dosed.
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Learn
Tools and guides for every step
Practical, educational help for understanding dosing, injections, and side effects.
FAQs
Answers to common GLP-1 questions
What is GLP-1 and how does it work?
GLP-1 is a hormone your gut releases after you eat. GLP-1 medications mimic it. They help your body release insulin when blood sugar rises, slow how quickly your stomach empties, and act on appetite centers in the brain, so you feel full sooner and stay full longer.
Who is a good candidate for GLP-1 therapy?
Generally, adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol.
GLP-1 medications aren't right for everyone. People who are pregnant, or who have a personal or family history of medullary thyroid cancer or MEN 2, are usually not candidates. Your provider reviews your full history before prescribing.
What are common side effects?
The most common are nausea, diarrhea, constipation, vomiting, and feeling full quickly. They're usually mild and ease as your body adjusts, which is why doses start low and increase gradually.
Severe stomach pain that doesn't go away, signs of an allergic reaction, or trouble swallowing need medical attention right away.
How long does it take to see results?
Many people notice less appetite within the first few weeks. Weight loss builds over months as your dose increases. The major clinical trials measured results after about 16 to 18 months of treatment.
Can I use GLP-1 if I have diabetes?
Often, yes. Semaglutide and tirzepatide were first approved to treat type 2 diabetes. If you take insulin or a sulfonylurea, your provider will adjust your plan, because combining them can raise the risk of low blood sugar.
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Reach out by email or send us a message, and our team will get back to you with clear, straightforward answers.